U-Pick Live is a program that aired on Nickelodeon from October 14, 2002 to May 27, 2005 on weekday afternoons from Nickelodeon Headquarters in New York City's Times Square. Starting at 5:00 p.m. EST to 7:00 p.m. EST. The show allowed viewers to pick via internet voting the Nickelodeon shows, usually cartoons, that would air. The hosts of the show also took part in sketches and gags, often including members of the studio audience and celebrity guests. Interviews with celebrity guests and musical performances were also frequent features.

It originally was U-Pick Friday from 1999 to late 2000, hosted by Henry and June of KaBlam!. The concept of U-Pick originated with the Nick in the Afternoon block in 1994. After U-Pick Live's cancellation, the concept of user-chosen programming would not return until its comeback as part of The '90s Are All That in 2011.