He & She is an American sitcom that aired on the CBS television network as part of its 1967-1968 lineup, originally sponsored by General Foods and Lever Brothers.

He & She is widely considered to be ahead of its time by broadcast historians. Its sophisticated approach to comedy was viewed as opening doors to the groundbreaking MTM family of sitcoms of the 1970s, beginning with The Mary Tyler Moore Show in 1970. The character of Oscar was openly the pattern for the Ted Baxter character, for which creator Leonard Stern granted permission.

CBS aired reruns of He & She in prime time from June 1970 to September 1970.